1988810334497112064

Membrane protein Series

Drug Target Encyclopedia Series (26) —CD127

Drug Target Encyclopedia Series (26) —CD127

CD127, also known as IL-7 receptor alpha, is a type I transmembrane protein that pairs with the common γ-chain (CD132) to form the functional IL-7 receptor complex. This axis is fundamental for T-cell development, survival, and long-term immune homeostasis, making CD127 a high-value membrane protein target with both mechanistic depth and translational relevance.

Membrane protein Series

Dec 30,2025

Drug Target Encyclopedia Series (25) —PSCA

Drug Target Encyclopedia Series (25) —PSCA

PSCA is a GPI-anchored cell surface membrane protein belonging to the Ly-6 family, with highly restricted expression in normal tissues but strong upregulation in multiple epithelial cancers. Its extracellular accessibility and tumor-selective expression make PSCA a validated and commercially attractive oncology membrane target.

Membrane protein Series

Dec 24,2025

Drug Target Encyclopedia Series (24) —CCR8

Drug Target Encyclopedia Series (24) —CCR8

CCR8 is a G protein–coupled chemokine receptor primarily expressed on tumor-infiltrating regulatory T cells (Tregs). In cancer immunotherapy, CCR8 has emerged as a highly selective immune checkpoint target, enabling Treg depletion within the tumor microenvironment (TME) while sparing peripheral immune tolerance.

Membrane protein Series

Dec 16,2025

Drug Target Encyclopedia Series (23) —FGFR4

Drug Target Encyclopedia Series (23) —FGFR4

FGFR4 is a transmembrane receptor tyrosine kinase in the FGFR family (FGFR1–4) and plays a central role in cell proliferation, metabolism regulation, tissue repair, and tumor progression. In oncology, FGFR4 has gained strong interest due to its oncogenic signaling, tumor-specific alterations, and its involvement in aggressive, therapy-resistant cancers.

Membrane protein Series

Dec 09,2025

Drug Target Encyclopedia Series (22) —TNFRSF8

Drug Target Encyclopedia Series (22) —TNFRSF8

TNFRSF8 (CD30) is a member of the tumor necrosis factor receptor superfamily (TNFRSF), primarily expressed on activated T and B cells, as well as in Hodgkin and Reed–Sternberg cells of Hodgkin lymphoma and anaplastic large cell lymphoma (ALCL). CD30 has emerged as a validated tumor-associated antigen (TAA) and a leading target in hematologic malignancies, driving the development of antibody-drug conjugates (ADCs), CAR-T cell therapies, and bispecific antibodies.

Membrane protein Series

Dec 05,2025

Drug Target Encyclopedia Series (21) —SDC1

Drug Target Encyclopedia Series (21) —SDC1

SDC1 (Syndecan-1, also known as CD138) is a transmembrane heparan sulfate proteoglycan that regulates cell adhesion, proliferation, and signaling in epithelial and plasma cells. Overexpression of SDC1 is a hallmark of multiple myeloma and several solid tumors, contributing to tumor progression, metastasis, and therapy resistance.

Membrane protein Series

Dec 05,2025

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