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RNA Platform

Levostar Biotech offers a fully integrated RNA production platform designed to meet the evolving needs of customers at every stage of development. From sequence to RNA, our end-to-end solutions ensure top-tier quality control throughout the process. Leveraging cutting-edge technologies—including mRNA, circular RNA, and self-amplifying RNA synthesis—seamlessly integrated with LNP delivery systems, ensuring top-tier quality control, optimal performance, and continuous innovation at every step.

monoPlasmid

Levostar has developed a proprietary “monoPlasmid” platform specifically designed for mRNA plasmids to address the heterogeneity caused by the presence of polyA sequences.

mRNA Synthesis

Levostar offers a fully integrated mRNA production platform designed to meet the evolving needs of customers at every stage of development.

circRNA Synthesis

Levostar offers custom circular RNA (circRNA) synthesis through our proprietary IVT manufacturing platform.

saRNA Synthesis

Self-amplifying RNA (saRNA) is a form of mRNA that encodes a replicase, enabling replication of the original RNA strand within cells.

LNP Encapsulation

Levostar has established a fully integrated technology platform covering gene synthesis, plasmid preparation, mRNA synthesis, and LNP encapsulation…

Comparison of different IVT RNA payload formats

	mRNA	Circular RNA	Self-Amplifying RNA
Structure	Linear; Open 5’ and 3’ end mRNA exonuclease degradation	Close loop; No free 5’ 3’ end Eliminating mRNA exonuclease degradation	Linear; Open 5’ and 3’ end mRNA exonuclease degradation
Ribosome recruiting	5’ Cap	Internal Ribosome Entry Site (IRES)	5’ Cap
UTR	Regulatory elements in the 5' and 3' UTR stabilize mRNA and enhance translation initiation	Include IRES + PIE + other elements	Replicon for further self-replication of the mRNA
ORF	Insert < 10 kb	Insert < 3 kb	Insert < 6 kb
polyA tail	Stabilizes RNA molecule & Prevents degradation	Not required	Stabilizes RNA molecule & Prevents degradation
Immunogenicity	Low	Medium	High
Protein Expression	Strong	Stronger	Strongest
Expression half-life	Short	Longer	Longest
Dosage requirement	High	Medium	Low

Resource

LNP Encapsulation

Learn about Levostar’s end-to-end LNP encapsulation platform, from sequence design and RNA production to scalable encapsulation, nanoparticle characterization, and final product delivery.

LNP Encapsulation

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LNP Encapsulation