1988810334497112064

Membrane protein Series

Drug Target Encyclopedia Series (32) —CD47

Drug Target Encyclopedia Series (32) —CD47

CD47 is a widely expressed cell-surface protein and a key innate immune checkpoint. By binding to SIRPα on macrophages and dendritic cells, CD47 delivers a “don’t eat me” signal that suppresses phagocytosis and helps tumor cells evade immune clearance. In oncology, CD47 has become one of the most closely watched myeloid checkpoint targets for reactivating macrophage-driven antitumor immunity.

Membrane protein Series

Mar 10,2026

Drug Target Encyclopedia Series (31) —CD22

Drug Target Encyclopedia Series (31) —CD22

CD22 is a B-cell–restricted transmembrane sialic acid–binding immunoglobulin-like lectin (Siglec-2) that functions as a negative regulator of B-cell receptor (BCR) signaling.

Membrane protein Series

Mar 03,2026

Drug Target Encyclopedia Series (30) —PTK7

Drug Target Encyclopedia Series (30) —PTK7

PTK7 is an evolutionarily conserved membrane protein belonging to the receptor tyrosine kinase family, but lacks catalytic kinase activity. Instead, PTK7 functions as a signaling scaffold, regulating Wnt/planar cell polarity (PCP) pathways, cell migration, polarity, and embryonic development. In oncology, PTK7 is best known for its aberrant overexpression on tumor cell surfaces, making it an attractive cell-surface drug target.

Membrane protein Series

Jan 27,2026

Drug Target Encyclopedia Series (29) —CD142

Drug Target Encyclopedia Series (29) —CD142

CD142, also known as Tissue Factor (TF), is a transmembrane glycoprotein that serves as the primary initiator of the extrinsic coagulation cascade. Beyond hemostasis, CD142 plays a pivotal role in thrombosis, cancer progression, inflammation, and vascular pathology, making it a high-value membrane protein target across multiple therapeutic areas.

Membrane protein Series

Jan 20,2026

Drug Target Encyclopedia Series (28) —FOLR1

Drug Target Encyclopedia Series (28) —FOLR1

FOLR1 (Folate Receptor Alpha, FRα) is a GPI-anchored membrane protein that mediates high-affinity folate uptake.Under physiological conditions, FOLR1 expression is low and polarized in normal epithelial tissues, but it is markedly upregulated in multiple solid tumors, making it a highly differentiated and clinically validated oncology target.

Membrane protein Series

Jan 13,2026

Drug Target Encyclopedia Series (27) —KLRK1

Drug Target Encyclopedia Series (27) —KLRK1

KLRK1, better known as NKG2D, is an activating immunoreceptor expressed on NK cells, CD8⁺ T cells, γδ T cells, and some NKT cells. It functions as a stress-surveillance receptor, recognizing ligands induced by cellular transformation, infection, or DNA damage. In immuno-oncology and immune modulation, KLRK1 represents a core axis of innate–adaptive immune activation and a high-value target for restoring anti-tumor cytotoxicity.

Membrane protein Series

Jan 06,2026

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