1988810334497112064

Membrane protein Series

Drug Target Encyclopedia Series (20) —GPC3

Drug Target Encyclopedia Series (20) —GPC3

GPC3 (Glypican-3) is a cell-surface heparan sulfate proteoglycan that regulates cell growth, differentiation, and Wnt/β-catenin signaling. It is highly expressed in hepatocellular carcinoma (HCC) and several embryonal tumors, while being absent in most normal adult tissues—making it an attractive tumor-specific target for precision oncology.

Membrane protein Series

Dec 05,2025

Drug Target Encyclopedia Series (19) —PSMA

Drug Target Encyclopedia Series (19) —PSMA

PSMA (Prostate-Specific Membrane Antigen) is a transmembrane glycoprotein highly expressed in prostate cancer and upregulated in advanced and metastatic disease. Its restricted expression in normal tissues and strong correlation with tumor progression make it a validated biomarker and therapeutic target in prostate oncology.

Membrane protein Series

Dec 05,2025

Drug Target Encyclopedia Series (18) —GPRC5D

Drug Target Encyclopedia Series (18) —GPRC5D

GPRC5D (G protein–coupled receptor, class C, group 5, member D) is an orphan receptor highly expressed in multiple myeloma (MM) cells but minimally in normal tissues, making it a promising immuno-oncology target for novel therapies.

Membrane protein Series

Dec 05,2025

Drug Target Encyclopedia Series (17) —CD276

Drug Target Encyclopedia Series (17) —CD276

CD276 (B7-H3) is an immune checkpoint molecule of the B7 family, highly expressed in many solid tumors but with limited expression in normal tissues. This makes it a promising immuno-oncology target for therapeutic intervention.

Membrane protein Series

Dec 05,2025

Drug Target Encyclopedia Series (16) —PDGFRA

Drug Target Encyclopedia Series (16) —PDGFRA

PDGFRA (platelet-derived growth factor receptor alpha) is a receptor tyrosine kinase that regulates cell proliferation, survival, and differentiation. Aberrant PDGFRA activation—through gene mutations, amplifications, or overexpression—drives oncogenic signaling across multiple tumor types, making it an important therapeutic target.

Membrane protein Series

Dec 05,2025

Drug Target Encyclopedia Series (15) — HER3（ERBB3）

Drug Target Encyclopedia Series (15) — HER3（ERBB3）

HER3 (human epidermal growth factor receptor 3, ERBB3) is a member of the ERBB receptor tyrosine kinase family, but unlike EGFR (ERBB1) or HER2 (ERBB2), HER3 has impaired kinase activity and relies on heterodimerization—especially with HER2—for signaling. This unique biology makes HER3 both a challenging and intriguing therapeutic target.

Membrane protein Series

Dec 05,2025

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