1988810334497112064

Membrane protein Series

Drug Target Encyclopedia Series (14) — Claudin 18.2

Drug Target Encyclopedia Series (14) — Claudin 18.2

Claudin 18.2 is a tight junction protein selectively expressed in differentiated gastric epithelial cells. Under pathological conditions such as gastric, pancreatic, and esophageal cancers, its restricted expression pattern and stable membrane localization make it an attractive therapeutic target.

Membrane protein Series

Dec 05,2025

Drug Target Encyclopedia Series (13) — CD79

Drug Target Encyclopedia Series (13) — CD79

CD79 (CD79A/CD79B) is a key component of the B cell receptor (BCR) complex, essential for B cell development, activation, and signal transduction. Aberrant CD79 signaling is closely linked to autoimmune diseases and B cell malignancies, making it an important therapeutic target.

Membrane protein Series

Dec 05,2025

Drug Target Encyclopedia Series (12) — CD63

Drug Target Encyclopedia Series (12) — CD63

CD63 is a member of the tetraspanin superfamily, primarily located in late endosomes, lysosomes, and extracellular vesicles (EVs). As one of the most widely used exosome markers, CD63 regulates vesicle trafficking, cell adhesion, and immune signaling.

Membrane protein Series

Dec 05,2025

Drug Target Encyclopedia Series (11) — HER2

Drug Target Encyclopedia Series (11) — HER2

HER2 is a transmembrane receptor tyrosine kinase belonging to the ErbB family, playing a key role in regulating cell growth, survival, and differentiation. Overexpression or amplification of HER2 drives oncogenesis in multiple tumor types, leading to aggressive disease progression.

Membrane protein Series

Dec 05,2025

Drug Target Encyclopedia Series (10) — SLAMF7

Drug Target Encyclopedia Series (10) — SLAMF7

SLAMF7 is an immunomodulatory receptor primarily expressed on natural killer (NK) cells, plasma cells, and subsets of T and B cells. Unlike many targets, SLAMF7 is not widely expressed in healthy tissues, making it an attractive candidate for immune-oncology therapies.

Membrane protein Series

Dec 05,2025

Drug Target Encyclopedia Series (9) — MSLN

Drug Target Encyclopedia Series (9) — MSLN

Mesothelin (MSLN) is a cell surface glycoprotein normally expressed at low levels in mesothelial cells lining the pleura, peritoneum, and pericardium. However, it is highly overexpressed in several solid tumors, making it an attractive target for cancer therapy.

Membrane protein Series

Dec 05,2025

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