1988810334497112064

Membrane protein Series

Drug Target Encyclopedia Series (8) — EpCAM

Drug Target Encyclopedia Series (8) — EpCAM

EpCAM is a transmembrane glycoprotein involved in cell-cell adhesion, proliferation, and differentiation. While typically expressed on the basolateral membrane of epithelial cells, it is overexpressed in many epithelial-derived cancers, making it a valuable biomarker and therapeutic target.

Membrane protein Series

Dec 05,2025

Drug Target Encyclopedia Series (7) — KIT

Drug Target Encyclopedia Series (7) — KIT

KIT, also known as CD117, is a type III receptor tyrosine kinase and the receptor for stem cell factor (SCF). It plays a crucial role in the development, survival, and function of various cell types, including hematopoietic stem cells, mast cells, melanocytes, and germ cells.

Membrane protein Series

Dec 05,2025

Drug Target Encyclopedia Series (6) — EGFR

Drug Target Encyclopedia Series (6) — EGFR

The Epidermal Growth Factor Receptor (EGFR) is a transmembrane receptor tyrosine kinase of the ErbB family, widely expressed in epithelial tissues. Upon ligand binding, EGFR activates downstream signaling pathways such as MAPK, PI3K/AKT, and JAK/STAT—governing key cellular processes including proliferation, survival, differentiation, and migration.

Membrane protein Series

Dec 05,2025

Drug Target Encyclopedia Series (5) — CD5

Drug Target Encyclopedia Series (5) — CD5

CD5 functions as a negative regulator of antigen-specific receptor-mediated activation, particularly in T cells, helping to prevent excessive immune responses and autoimmunity. Emerging evidence also suggests its involvement in modulating B cell tolerance and influencing autoimmune disease development.

Membrane protein Series

Dec 05,2025

Drug Target Encyclopedia Series (4) — CD8

Drug Target Encyclopedia Series (4) — CD8

CD8 is a transmembrane glycoprotein best known for its role as a co-receptor on cytotoxic T lymphocytes (CTLs), where it recognizes antigen-presenting MHC class I molecules.

Membrane protein Series

Dec 03,2025

Drug Target Encyclopedia Series (3) — FXTD3

Drug Target Encyclopedia Series (3) — FXTD3

FXYD3 (also known as Mat-8 or Phosphohippolin) is a small transmembrane protein that regulates ion transport, particularly by modulating the Na+/K+-ATPase pump.

Membrane protein Series

Dec 03,2025

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