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Drug Target Encyclopedia Series (39) —CDH6

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Release Time：

2026-06-08 15:21

 

  

CDH6, also known as **Cadherin-6**, is a calcium-dependent cell adhesion molecule involved in cell-cell interaction, tissue development, and tumor progression. With its elevated expression in several solid tumors and relatively attractive cell-surface localization, CDH6 has become an emerging target in oncology drug development, especially for antibody-based therapies.

CDH6 is highly relevant in ovarian cancer, renal cell carcinoma, endometrial cancer, and other solid tumor research. Its role in tumor invasion, metastasis, and cancer progression makes it a promising membrane protein target for precision oncology strategies.

🧬 CDH6 is highly relevant in:

• Ovarian cancer

• Renal cell carcinoma

• Endometrial cancer

• Cholangiocarcinoma research

• Thyroid cancer research

• Solid tumor drug discovery

🎯 Targeting CDH6 in drug development:

🧪 Antibody-drug conjugates – Deliver cytotoxic payloads to CDH6-expressing tumor cells and support tumor-selective killing.

🧪 Monoclonal antibodies – Explore CDH6 as a surface antigen for antibody-based targeting strategies.

🧪 Patient selection strategies – Use CDH6 expression to identify suitable patient populations for targeted therapy development.

🧪 Combination approaches – Evaluate CDH6-targeted modalities with chemotherapy, immunotherapy, or other oncology treatment backbones.

💥 Challenges include:

• Heterogeneous CDH6 expression

• On-target/off-tumor safety concerns

• Payload and linker optimization for ADCs

• Patient selection and biomarker validation

• Translating early clinical activity into durable benefit

🔬 CDH6 is gaining increasing attention as a promising membrane protein target in solid tumor therapeutics. As CDH6-targeted ADCs and related strategies continue to advance, this target may play an important role in expanding treatment options for ovarian cancer, renal cancer, and other difficult-to-treat solid tumors.

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Drug Target Encyclopedia Series (40) —CD80

Drug Target Encyclopedia Series (38) —DLL3

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