mRNA-CD73

Cat.#	Gene	Scale	State
LS-RMAbt-137	mRNA-CD73	1mg	Lyophilized/Liquid

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Description
Product Overview
Sequence
Data Chart
Storage & Logistic
Documents

Cat.# Gene Scale State

LS-RMAbt-137 mRNA-CD73 1mg Lyophilized/Liquid
Product Overview

mRNA-CD73 is an in vitro transcribed (IVT) messenger RNA encoding the ecto-5'-nucleotidase CD73 (NT5E), a GPI-anchored cell surface enzyme that converts extracellular AMP to immunosuppressive adenosine, serving as a critical checkpoint in tumor microenvironments and inflammatory niches. This synthetic mRNA enables controlled expression of CD73 for research in:

Cancer immunotherapy (overcoming adenosine-mediated T cell suppression via CD73 blockade)

Autoimmune/inflammatory disorders (e.g., rheumatoid arthritis, IBD) Tissue repair mechanisms (modulating epithelial barrier function) with key advantages including dose-dependent adenosine flux control (vs. static recombinant protein systems) and compatibility with LNP delivery for in vivo mechanistic studies.

Product Details

Storage Buffer: ddH₂O ph=7.0

mRNA length: 2007 nt

Amino acid sequence size: 569 aa

Handling and Storage: store at – 80℃ for long term
Amino acid sequence

MEAPAQLLFLLLLWLPDTTGWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDI NVVSTYISKMKVIYPAVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ*
Storage & Logistic

Storage Conditions: 2°C to 8°C, protect from light

Shipping Conditions: Ambient

Expiration Date of Liquid Product: 12 Months

Retest Date of Powder Product: 18 Months